Hung-Pin Tu


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Kaohsiung Medical University


Epidemiology, Gout, Familial-tumoral calcinosis

Summary of research interests

Epidemiology and management of gout, mechanisms of monosodium urate crystal [MSU]-induced immunity profiles, risk factors and management of familial-tumoral calcinosis, mechanisms of abnormal calcium-related disorder.


  1. 1.         Cheng LS, Chiang SL, Tu HP, Chang SJ, Wang TN, Ko AM, Chakraborty R, Ko YC. Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25. Am J Hum Genet. 2004;75(3):498-503. [PMID: 15252757].

    2.         Ko YC, Huang MC, Wang TN, Chang SJ, Tsai LY, Tu HP. Prevalence and risk factors associated with dyslipidaemia in children and adolescents among ethnic groups in Taiwan. Public Health. 2005;119(6):489-97. [PMID: 15826890].

    3.         Huang MC, Wang TN, Liu YL, Pa TH, Tu HP, Huang YC, Chang WT, Ko YC. Effect of SstI polymorphism of the apolipoprotein CIII gene and environmental factors on risks of hypertriglyceridemia in Taiwan aborigines. Circ J. 2006;70(8):1030-6. [PMID: 16864937].

    4.         Chen PH, Lin YC, Tu HP, Chiang SL, Ko AM, Hsu CL, Chang YF, Ko YC. Important prognostic factors for the long-term survival of subjects with primary liver cancer in Taiwan: a hyperendemic area. Eur J Cancer. 2007;43(6):1076-84. [PMID: 17329095].

    5.         Chen PH, Shieh TY, Ho PS, Tsai CC, Yang YH, Lin YC, Ko MS, Tsai PC, Chiang SL, Tu HP, Ko YC. Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. BMC Cancer. 2007;7:101. [PMID: 17573960].

    6.         Chiang SL, Jiang SS, Wang YJ, Chiang HC, Chen PH, Tu HP, Ho KY, Tsai YS, Chang IS, Ko YC. Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci. 2007;100(1):66-74. [PMID: 17682004].

    7.         Tovosia S, Chen PH, Ko AM, Tu HP, Tsai PC, Ko YC. Prevalence and associated factors of betel quid use in the Solomon Islands: a hyperendemic area for oral and pharyngeal cancer. Am J Trop Med Hyg. 2007;77(3):586-90. [PMID: 17827384].

    8.         Chiang SL, Chen PH, Lee CH, Ko AM, Lee KW, Lin YC, Ho PS, Tu HP, Wu DC, Shieh TY, Ko YC. Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 2008;68(20):8489-98. [PMID: 18922923].

    9.         Lan CC, Ko YC, Tu HP, Wu CS, Lee CH, Yu HS. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. Br J Dermatol. 2009;160(6):1180-7. [PMID: 19416273].

    10.       Tu HP, Ko AM, Wang SJ, Lee CH, Lea RA, Chiang SL, Chiang HC, Wang TN, Huang MC, Ou TT, Lin GT, Ko YC. Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines. Hum Genet. 2010;127(2):223-9. [PMID: 19915868].

    11.       Tu HP, Chen CJ, Lee CH, Tovosia S, Ko AM, Wang SJ, Ou TT, Lin GT, Chiang SL, Chiang HC, Chen PH, Chang SJ, Lai HM, Ko YC. The SLC22A12 gene is associated with gout in Han Chinese and Solomon Islanders. Ann Rheum Dis. 2010;69(6):1252-4. [PMID: 19762362].

    12.       Tu HP, Chen CJ, Tovosia S, Ko AM, Lee CH, Ou TT, Lin GT, Chang SJ, Chiang SL, Chiang HC, Chen PH, Wang SJ, Lai HM, Ko YC. Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders. Ann Rheum Dis. 2010;69(5):887-90. [PMID: 19723617].

    13.       Huang MC, Wang TN, Lee KT, Wu YJ, Tu HP, Liu CS, Chiang HC, Ko YC. Adiponectin gene SNP276 variants and central obesity confer risks for hyperglycemia in indigenous Taiwanese. Kaohsiung J Med Sci. 2010;26(5):227-36. [PMID: 20466332].

    14.       Tai CM, Lee YC, Tu HP, Huang CK, Wu MT, Chang CY, Lee CT, Wu MS, Lin JT, Wang WM. The relationship between visceral adiposity and the risk of erosive esophagitis in severely obese Chinese patients. Obesity (Silver Spring). 2010;18(11):2165-9. [PMID: 20559298].

    15.       Lan CC, Tu HP, Lee CH, Wu CS, Ko YC, Yu HS, Lu YW, Li WC, Chen GS. Hand dermatitis among university hospital nursing staff with or without atopic eczema: assessment of risk factors. Contact Dermatitis. 2011;64(2):73-9. [PMID: 21138443].

    16.       Lee CH, Lee KW, Fang FM, Wu DC, Shieh TY, Huang HL, Chen CH, Chen PH, Chen MK, Kuo SJ, Chang CH, Tsai YS, Chiang SL, Tu HP, Chen BH, Ko YC. The use of tobacco-free betel-quid in conjunction with alcohol/tobacco impacts early-onset age and carcinoma distribution for upper aerodigestive tract cancer. J Oral Pathol Med. 2011;40(9):684-92. [PMID: 21385213].

    17.       Wang SJ, Tu HP, Ko AM, Chiang SL, Chiou SJ, Lee SS, Tsai YS, Lee CP, Ko YC. Lymphocyte alpha-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses. J Mol Med (Berl). 2011;89(12):1241-51. [PMID: 21822924].

    18.       Lan CC, Tu HP, Wu CS, Ko YC, Yu HS, Lu YW, Li WC, Chen YC, Chen GS. Distinct SPINK5 and IL-31 polymorphisms are associated with atopic eczema and non-atopic hand dermatitis in Taiwanese nursing population. Exp Dermatol. 2011;20(12):975-9. [PMID: 22017185].

    19.       Chen PH, Tu HP, Wang SJ, Ko AM, Lee CP, Chiang TA, Tsai YS, Lee CH, Shieh TY, Ko CH, Chiang SL, Ko YC. Monoamine oxidase A variants are associated with heavy betel quid use. Addict Biol. 2012;17(4):786-97. [PMID: 21521428].

    20.       Chang CC, Cho SF, Chen YW, Tu HP, Lin CY, Chang CS. SUV on Dual-Phase FDG PET/CT Correlates With the Ki-67 Proliferation Index in Patients With Newly Diagnosed Non-Hodgkin Lymphoma. Clin Nucl Med. 2012;37(8):e189-95. [PMID: 22785526].

    21.       Ke HL, Tu HP, Lin HH, Chai CY, Chang LL, Li WM, Li CC, Lee YC, Yeh HC, Wu WJ, Bau DT. Cyclooxygenase-2 (COX-2) Up-regulation Is a Prognostic Marker for Poor Clinical Outcome of Upper Tract Urothelial Cancer. Anticancer Res. 2012;32(9):4111-6. [PMID: 22993369].

    22.       Chen YC, Tu HP, Wu CS, Ko YC, Yu HS, Lu YW, Li WC, Chen GS, Lan CC. Association between non-atopic hand eczema and interleukin-13 gene polymorphism in Taiwanese nursing population. Exp Dermatol. 2012;21(12):972-4. [PMID: 23171465].

    23.       Min-Shan Ko A, Tu HP, Liu TT, Chang JG, Yuo CY, Chiang SL, Chang SJ, Liu YF, Min-Jen Ko A, Lee CH, Lee CP, Chang CM, Tsai SF, Ko YC. ALPK1 genetic regulation and risk in relation to gout. Int J Epidemiol. 2013;42(2):466-74. [PMID: 23569188].

    24.       Chen SH, Wu WJ, Tu HP, Li WM, Huang CN, Li CC, Lin HH, Ke HL. Glutathione s-transferase expression in upper urinary tract urothelial carcinomas: a taiwan study. Asian Pac J Cancer Prev. 2013;14(11):6475-9. [PMID: 24377553].

    25.       Chen SH, Wu WJ, Chou YH, Yeh HC, Tsai CC, Chueh KS, Hou NT, Chiu SJ, Tu HP, Li CC. Comparison one-step procedure with two-step procedure in percutaneous nephrolithotomy. Urolithiasis. 2014;42(2):121-6. [PMID: 24190698].

    26.       Cheng KI, Wang HC, Chuang YT, Chou CW, Tu HP, Yu YC, Chang LL, Lai CS. Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats. Eur J Pain. 2014;18(2):162-73. [PMID: 23868758].

    27.       Lee JD, Chung LY, Wang LC, Lin RJ, Wang JJ, Tu HP, Wu ZD, Yen CM. Sequence analysis in partial genes of five isolates of Angiostrongylus cantonensis from Taiwan and biological comparison in infectivity and pathogenicity between two strains. Acta Trop. 2014;133:26-34. [PMID: 24503290].

    28.       Yen JY, Tu HP, Chen CS, Yen CF, Long CY, Ko CH. The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder. Eur Arch Psychiatry Clin Neurosci. 2014;264(8):729-39. [PMID: 24158751].

    29.       Tu HP, Ko AM, Chiang SL, Lee SS, Lai HM, Chung CM, Huang CM, Lee CH, Kuo TM, Hsieh MJ, Ko YC. Joint Effects of Alcohol Consumption and ABCG2 Q141K on Chronic Tophaceous Gout Risk. J Rheumatol. 2014;41(4):749-58. [PMID: 24532835].

    30.       Yang YC, Tu HP, Hong CH, Chang WC, Fu HC, Ho JC, Chang WP, Chuang HY, Lee CH. Female gender and acne disease are jointly and independently associated with the risk of major depression and suicide: a national population-based study. Biomed Res Int. 2014;2014:504279. [PMID: 24678508].

    31.       Chung HF, Long KZ, Hsu CC, Mamun AA, Chiu YF, Tu HP, Chen PS, Jhang HR, Hwang SJ, Huang MC. Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes. Diabetes Res Clin Pract. 2014;105(2):261-70. [PMID: 24894086].

    32.       Chang CC, Tu HP, Chen YW, Lin CY, Hou MF. Tumour and lymph node uptakes on dual-phased 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography correlate with prognostic parameters in breast cancer. J Int Med Res. 2014;42(6):1209-21. [PMID: 25339454].

    33.       Chen CH, Chen YJ, Tu HP, Huang MH, Jhong JH, Lin KL. Benefits of exercise training and the correlation between aerobic capacity and functional outcomes and quality of life in elderly patients with coronary artery disease. Kaohsiung J Med Sci. 2014;30(10):521-30. [PMID: 25438684].

    34.       Chiang SL, Ou TT, Wu YJ, Tu HP, Lu CY, Huang CM, Kuo TM, Wang TN, Chou CH, Ko YC. Increased level of MSU crystal-bound protein apolipoprotein A-I in acute gouty arthritis. Scand J Rheumatol. 2014;43(6):498-502. [PMID: 25178483].

    35.       Geng JH, Tu HP, Shih PM, Shen JT, Jang MY, Wu WJ, Li CC, Chou YH, Juan YS. Noncontrast computed tomography can predict the outcome of shockwave lithotripsy via accurate stone measurement and abdominal fat distribution determination. Kaohsiung J Med Sci. 2015;31(1):34-41. [PMID: 25600918].

    36.       Tu FY, Lin GT, Lee SS, Tung YC, Tu HP, Chiang HC. Prevalence of gout with comorbidity aggregations in southern Taiwan. Joint Bone Spine. 2015;82(1):45-51. [PMID: 25238950].

    37.       Lee HY, Li CC, Huang CN, Ke HL, Li WM, Liang PI, Yang SF, Tu HP, Wu WJ, Yeh HC. Prognostic significance of lymphovascular invasion in upper urinary tract urothelial carcinoma is influenced by tumor location. Ann Surg Oncol. 2015;22(4):1392-400. [PMID: 25239005].

    38.       Tung YC, Tu HP, Tsai WC, Chen CS, Su CH, Shi HY, Lin CL. Increased Incidence of Herpes Zoster and Postherpetic Neuralgia in Adult Patients following Traumatic Brain Injury: A Nationwide Population-Based Study in Taiwan. PLoS One. 2015;10(6):e0129043. [PMID: 26065420].

    39.       Tai CM, Huang CK, Tu HP, Hwang JC, Chang CY, Yu ML. PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease. Surg Obes Relat Dis. 2015;11(4):888-94. [PMID: 25240529].

    40.       Hwang JC, Sung WW, Tu HP, Hsieh KC, Yeh CM, Chen CJ, Tai HC, Hsu CT, Shieh GS, Chang JG, Yeh KT, Liu TC. The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma. PLoS One. 2015;10(10):e0139435. [PMID: 26431531].

    41.       Lin SF, Chen YJ, Tu HP, Lee CL, Hsieh CL, Wu WL, Chen CH. The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial. PLoS One. 2015;10(11):e0142475. [PMID: 26556601].

    42.       Kuo TM, Yeh KT, Hsu HT, Chiang SL, Chang JG, Huang CM, Tu HP, Liu CS, Ko YC. ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production. J Steroid Biochem Mol Biol. 2015;154:150-8. [PMID: 26275947].

    43.       Cheng YC, Huang CN, Wu WJ, Li CC, Ke HL, Li WM, Tu HP, Li CF, Chang LL, Yeh HC. The Prognostic Significance of Inflammation-Associated Blood Cell Markers in Patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol. 2016;23(1):343-51. [PMID: 26242371].

    44.       Yu S, Yu HS, Tu HP, Wu CS, Lan CC. Association study between melanocortin-1 receptor gene polymorphisms and occurrence of vitiligo in a Taiwanese population: possible explanation for lack of increased UV-related damage in vitiligo skin. J Eur Acad Dermatol Venereol. 2015. [PMID: 26670452].

    45.       Chang SJ, Ou-Yang F, Tu HP, Lin CH, Huang SH, Kostoro J, Hou MF, Chai CY, Kwan AL. Decreased expression of autophagy protein LC3 and stemness (CD44+/CD24-/low) indicate poor prognosis in triple-negative breast cancer. Hum Pathol. 2016;48:48-55. [PMID: 26772398].

    46.       Hong CH, Tu HP, Lin JR, Lee CH. An estimation of the incidence of tuberous sclerosis complex by a nationwide retrospective cohort study from 1997 to 2010. Br J Dermatol. 2016. [PMID: 26800857].

    47.       Tai CM, Huang CK, Tu HP, Hwang JC, Yeh ML, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients. Medicine (Baltimore). 2016;95(12):e3120. [PMID: 27015186].

    48.       Tu HP, Lin CH, Hsieh HM, Jiang HJ, Wang PW, Huang CJ. Prevalence of anxiety disorder in patients with type 2 diabetes: a nationwide population-based study in Taiwan 2000-2010. Psychiatr Q. 2016. [PMID: 27155828].

    49.       Tu HP, Chung CM, Min-Shan Ko A, Lee SS, Lai HM, Lee CH, Huang CM, Liu CS, Ko YC. Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk. J Hum Genet. 2016. [PMID: 27225847].

    50.       Tu HP, Tung YC, Tsai WC, Lin GT, Ko YC, Lee SS. Alcohol-related diseases and alcohol dependence syndrome is associated with increased gout risk: A nationwide population-based cohort study. Joint Bone Spine. 2016. [PMID: 27238189].



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