Hung-Pin Tu

Professor

https://wac.kmu.edu.tw/qur/profiles.php?id=915013

https://orcid.org/0000-0003-1044-2673

Get in Touch

  • Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    Office: IR857
    Tel: 886-7-3121101 (ext.2777)
  • Email: p915013@kmu.edu.tw

Education

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University (PhD, 2011/07)

Keywords

Epidemiology; Gout; Type 2 diabetes mellitus.

Summary of research interests

My research focuses on the bidirectional pathophysiological relationship between gout and type 2 diabetes mellitus. Specifically, I aim to explore how gout—through its medical management and the use of antigout agents (e.g., uricosuric drugs)—influences the risk of developing type 2 diabetes, and conversely, how diabetes—through its clinical care, antidiabetic medications, the uricosuric effect of glycosuria, and impaired inflammatory responses—affects the risk of developing gout. Additionally, I am interested in evaluating the independent and combined effects of gout and diabetes on the risk of cardiovascular events and all-cause mortality.

Recent Publications (Last Three Years)

1.         Chen TY, Chen SC, Wang CW, Tu HP, Chen PS, Hu SC, Li CH, Wu DW, Hung CH, Kuo CH. The impact of the synergistic effect of SO(2) and PM(2.5)/PM(10) on obstructive lung disease in subtropical Taiwan. Front Public Health 2023;11:1229820. DOI: 10.3389/fpubh.2023.1229820.

2.         Cheng KC, Tu HP, Lin TH, Cheng KH. The Incident Ocular Diseases Related to Chemotherapy in Cancer Patients are Associated with Increasing Risk of Incident Stroke. Acta Cardiol Sin 2023;39(3):435-448. DOI: 10.6515/ACS.202305_39(3).20221005A.

3.         Dlamini ST, Htet KM, Theint ECC, Mayadilanuari AM, Li WM, Tung YC, Tu HP. Herpes Zoster Risk in Patients with Rheumatoid Arthritis and Its Association with Medications Used. Int J Environ Res Public Health 2023;20(3). DOI: 10.3390/ijerph20032123.

4.         Hsu HF, Tu HP, Chen KM, Belcastro F. Medications for Chronic Conditions and Mortality in Older Adults. Nurs Res 2023;72(1):30-37. DOI: 10.1097/NNR.0000000000000618.

5.         Huang CH, Yu S, Yu HS, Tu HP, Yeh YT, Yu HS. Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation. Front Cell Infect Microbiol 2023;13:1320713. DOI: 10.3389/fcimb.2023.1320713.

6.         Ko AM, Tu HP, Ko YC. Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis. Cells 2023;12(8). DOI: 10.3390/cells12081208.

7.         Lin EC, Tu HP, Hong CH. Limited effect of reducing pulmonary tuberculosis incidence amid mandatory facial masking for COVID-19. Respir Res 2023;24(1):54. DOI: 10.1186/s12931-023-02365-x.

8.         Luo KH, Wu CH, Yang CC, Chen TH, Tu HP, Yang CH, Chuang HY. Exploring the association of metal mixture in blood to the kidney function and tumor necrosis factor alpha using machine learning methods. Ecotoxicol Environ Saf 2023;265:115528. DOI: 10.1016/j.ecoenv.2023.115528.

9.         Su WY, Wu DW, Tu HP, Chen SC, Hung CH, Kuo CH. Association between ambient air pollutant interaction with kidney function in a large Taiwanese population study. Environ Sci Pollut Res Int 2023;30(34):82341-82352. DOI: 10.1007/s11356-023-28042-6.

10.       Wang YW, Ou YC, Lin H, Huang KS, Fu HC, Wu CH, Chen YY, Huang SW, Tu HP, Tsai CC. Characteristics of Cancer-Related Fatigue and an Efficient Model to Identify Patients with Gynecological Cancer Seeking Fatigue-Related Management. Cancers (Basel) 2023;15(7). DOI: 10.3390/cancers15072181.

11.       Hung CC, Tu HP, Chung CM. Selective Serotonin Reuptake Inhibitors for Cessation of Betel Quid Use in Patients with Major Depressive Disorder in Taiwan. Biomedicines 2024;12(11). DOI: 10.3390/biomedicines12112633.

12.       Lin SY, Huang HY, Chang LL, Wang YL, Chen TC, Chang K, Tu HP, Lu PL. The impact of the fluconazole trailing effect on the persistence of Candida albicans bloodstream infection when treated with fluconazole. Clin Microbiol Infect 2024;30(7):945-950. DOI: 10.1016/j.cmi.2024.03.023.

13.       Lin YC, Tu HP, Wang TN. Blood lipid profile, HbA1c, fasting glucose, and diabetes: a cohort study and a two-sample Mendelian randomization analysis. J Endocrinol Invest 2024;47(4):913-925. DOI: 10.1007/s40618-023-02209-x.

14.       Lin YY, Cho SF, Hsieh YL, Chuang YS, Hsu CE, Liu YC, Sung CC, Huang YH, Ku W, Hsieh MH, Huang YC, Tu HP, Wang CL, Ho CK. Positive vaccine beliefs linked to reduced mental stress in healthcare professionals during COVID-19: a retrospective study. Front Psychiatry 2024;15:1402194. DOI: 10.3389/fpsyt.2024.1402194.

15.       Luo KH, Tu HP, Chang HC, Yang CC, Weng WC, Chen TH, Yang CH, Chuang HY. Mediation analysis for TNF-alpha as a mediator between multiple metal exposure and kidney function. Ecotoxicol Environ Saf 2024;283:116837. DOI: 10.1016/j.ecoenv.2024.116837.

16.       Luo KH, Tu HP, Chung YC, Huang MH, Yang CC, Chen TH, Yang CH, Chuang HY. Unveiling the interaction and combined effects of multiple metals/metalloids exposure to TNF-alpha and kidney function in adults using bayesian kernel machine regression and quantile-based G-computation. J Trace Elem Med Biol 2024;86:127552. DOI: 10.1016/j.jtemb.2024.127552.

17.       Yen PS, Tu HP, Huang SH, Lee SS. Timely Shaver Treatment Removes Chronic Tophaceous Mass Improve Surgical Outcomes. Int J Med Sci 2024;21(10):1799-1805. DOI: 10.7150/ijms.95372.

18.       Chen CJ, Wu JH, Huang HY, Lu PL, Tu HP, Lin SY. Evaluation of PERFORMANCE of the IMMY and Dynamiker Aspergillus Galactomannan lateral flow assays for the diagnosis of invasive Aspergillosis. Diagn Microbiol Infect Dis 2025;112(3):116805. DOI: 10.1016/j.diagmicrobio.2025.116805.

19.       Chen IH, Li MS, Tseng CL, Tu HP, Sheu SJ. Analysis of retinal microstructure and electrophysiology in eyes following pars plana vitrectomy and membrane peeling for vitreomacular interface disorders. BMC Ophthalmol 2025;25(1):235. DOI: 10.1186/s12886-025-04042-7.

20.       Yang CY, Chen JH, Chen CY, Kao CY, Huang SF, Chang WY, Tu HP, Huang JF, Yu ML, Tai CM. Serial changes in metabolic dysfunction-associated steatotic liver disease after sleeve gastrectomy and their associations with abdominal adiposity: a prospective cohort study. Surg Obes Relat Dis 2025;21(5):537-546. DOI: 10.1016/j.soard.2024.11.007.

21.       Yen CC, Tu HP, Lin TC, Li KY, Chen SC. Routine Clinic Surveillance on Arteriovenous Graft Patency in Hemodialysis Patients with Previous Access Complications. Int J Med Sci 2025;22(5):1064-1071. DOI: 10.7150/ijms.106651.

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